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====Metaestabilidade====
SomeAlgunhas tertiaryestruturas proteinterciarias structuresde mayproteínas existpoden inexistir long-liveden statesestados thatde arelonga notvida thedistintos expecteddo mostestado stablemáis stateestable esperado. ForPor exampleexemplo, manymoitas [[serpinserpina]]s (serineinhibidores da serina protease inhibitors) show thismostran [[metastabilitymetaestabilidade]]. TheySofren undergo aun [[conformationalcambio changeconformacional]] whencando aunha loop[[protease]] ofcorta theun proteinbucle isda cut by a [[protease]]proteína.<ref name="whis">Whisstock J. [http://www.ncbi.nlm.nih.gov/pubmed/17079131 "Molecular gymnastics: serpin structure, folding and misfolding."] Current Opinions in Structural Biology '''16'''(6) 2006 pp761 - 768.</ref><ref>{{cite journal |author=Gettins PG |title=Serpin structure, mechanism, and function |url=http://www.ncbi.nlm.nih.gov/pubmed/12475206|journal=Chem Rev |volume=102 |issue=12 |pages=4751–4804 |year=2002 |pmid=12475206 |doi=10.1021/cr010170 }}</ref><ref>{{cite journal |author=Whisstock JC, Skinner R, Carrell RW, Lesk AM |title=Conformational changes in serpins: I. The native and cleaved conformations of alpha(1)-antitrypsin |url=http://www.ncbi.nlm.nih.gov/pubmed/10623554|journal=J Mol Biol. |year=2000 |volume=296 |pmid=10669617 |pages=685–699 |doi=10.1006/jmbi.1999.3520 |issue=2}}</ref>
===Ambiente citoplasmático===
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