Complexo de ataque á membrana: Diferenzas entre revisións

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==Estrutura e función==
ItEstá iscomposto composedpor of a complex of four complementcatro [[proteinproteína]]s (C5b, C6, C7, ande C8), thatque bindse tounen theá outersuperficie surfaceexterna of theda [[plasmamembrana membraneplasmática]], andxunto manycon copiesmoitas ofcopias adunha fifthquinta proteinproteína chamada (C9), thatque hookse upenganchan tounhas onea another,outras formingformando aun ringanel inque theatravesa membranea membrana. C6-, C7, C8 e C9 allconteñen containun a[[dominio commonproteico|dominio]] [[MACPF]] domaincomún.<ref>{{cite journal |author=Tschopp J, Masson D, Stanley KK |title=Structural/functional similarity between proteins involved in complement- and cytotoxic T-lymphocyte-mediated cytolysis |journal=Nature |volume=322 |issue=6082 |pages=831–4 |year=1986 |pmid=2427956 |doi=10.1038/322831a0}}</ref> ThisEsta regionrexión isé [[HomologyHomoloxía (biologybioloxía)|homologoushomóloga]] to cholesterol-dependentás [[cytolysincitolisina]]s fromdependentes de colesterol das bacterias [[Gram-positive bacteriapositiva]]s.<ref name="macpfstructure">{{cite journal |author=Carlos J. Rosado, Ashley M. Buckle, Ruby H. P. Law, Rebecca E. Butcher, Wan-Ting Kan, Catherina H. Bird, Kheng Ung, Kylie A. Browne, Katherine Baran, Tanya A. Bashtannyk-Puhalovich, Noel G. Faux, Wilson Wong, Corrine J. Porter, Robert N. Pike, Andrew M. Ellisdon, Mary C. Pearce, Stephen P. Bottomley, Jonas Emsley, A. Ian Smith, Jamie Rossjohn, Elizabeth L. Hartland, Ilia Voskoboinik, Joseph A. Trapani, Phillip I. Bird, Michelle A. Dunstone, and James C. Whisstock |title=A Common Fold Mediates Vertebrate Defense and Bacterial Attack |journal=Science |year=2007 |pmid= 17717151 |doi=10.1126/science.1144706 |volume=317 |pages=1548–51 |issue=5844}}</ref>
 
A estrutura en anel formada por C9 é un poro na membrana que permite a libre [[difusión]] de moléculas dentro e fóra da célula. Se se forman moitos destes poroa, a célula non pode sobrevivir.
The ring structure formed by C9 is a pore in the membrane that allows free [[diffusion]] of molecules in and out of the cell. If enough pores form, the cell is no longer able to survive.
 
==Iniciación: C5-C7==