Diferenciación celular: Diferenzas entre revisións
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Liña 77:
O primeiro candidato principal é a [[vía de sinalización Wnt]]. A vía Wnt está implicada en todos os estadios de diferenciación, e o [[ligando]] Wnt3a pode substituír a sobreexpresión de c-Myc na xeración de células nais pluripotentes inducidas.<ref name = "Mohammad"/> Por outra parte, a alteración da [[Beta-catenina|ß-catenina]], un compoñente da vía de sinalización Wnt, dá lugar a unha diminución da proliferación dos proxenitores neurais.
Os [[factor de crecemento|factores de crecemento]] compoñen o segundo
Several other signaling pathways are also considered to be primary candidates. Cytokine [[leukemia inhibitory factor]]s are associated with the maintenance of mouse ESCs in an undifferentiated state. This is achieved through its activation of the Jak-STAT3 pathway, which has been shown to be necessary and sufficient towards maintaining mouse ESC pluripotency.<ref name = "Niwa">{{cite journal |pmid=9649508 |doi=10.1101/gad.12.13.2048 |author=Niwa H, Burdon T, Chambers I, Smith A |title=Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3 |journal=Genes Dev |year=1998 |volume=12 |issue=13 |pages=2048–60 |pmc=316954}}</ref> [[Retinoic acid]] can induce differentiation of human and mouse ESCs,<ref name = "Mohammad"/> and [[Notch signaling]] is involved in the proliferation and self-renewal of stem cells. Finally, [[Sonic hedgehog]], in addition to its role as a morphogen, promotes embryonic stem cell differentiation and the self-renewal of somatic stem cells.<ref name = "Mohammad"/>
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