Estercobilina: Diferenzas entre revisións

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Miguelferig (conversa | contribucións)
traducido de en:Stercobilin
 
Miguelferig (conversa | contribucións)
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== Metabolismo ==
StercobilinA resultsestercobilina fromorixínase breakdownda ofdegradación thedo hemegrupo moiety[[hemo]] ofda hemoglobinproteína found[[hemoglobina]] indos erythrocytes[[eritrocito]]s.<ref name="multiple 1">Kay IT, Weimer M, Watson CJ (1963). “The formation in vitro of stercobilin from bilirubin.” J Biol Chem. 238:1122-3. PMID 14031566</ref> Os [[Macrophagesmacrófago]] break down senescents [[erythrocytesfagocitose|fagocitan]] andos breakrestos thedos hemeeritrocitos downsenescentes intoe degradan o grupo hemo primeiro a [[biliverdinbiliverdina]], whicha rapidlycal reducesrapidamente tose reduce para freeformar [[bilirubinbilirrubina]] libre.<ref name="multiple">Boron W, Boulpaep E. Medical Physiology: a cellular and molecular approach, 2005. 984-986. Elsevier Saunders, United States. ISBN 1-4160-2328-3</ref> BilirubinA bindsbilirrubina tightlyúnese tomoi estreitamente plasmaa proteinsproteínas (especiallydo albumin)plasma in(especialmente theá blood[[albumina]]) streamno andtorrente issanguíneo transportede toé thetransportada liverao fígado, whereonde ité isconxugada conjugatedcun withou onedous orresiduos twode glucuronic[[ácido acidglicurónico]], residuesdando intolugar a [[bilirubinbilirrubina diglucuronidediglicurónido]], ande secretedsegregado intoao the[[intestino small intestinedelgado]] ascoa [[bile]].<ref name="multiple 2">Seyfried H, Klicpera M, Leithner C, Penner E (1976). "Bilirubin metabolism". Wien Klin Wochenschr. 88:477-82. PMID 793184</ref> In the small intestine, some bilirubin glucuronide is converted back to bilirubin via bacterial enzymes in the terminal ileum.<ref name="multiple">Boron W, Boulpaep E. Medical Physiology: a cellular and molecular approach, 2005. 984-986. Elsevier Saunders, United States. ISBN 1-4160-2328-3</ref> ThisEsta bilirubinbilirrubina isconvértese furtherdespois converted to colorlessen [[urobilinogenurobilinóxeno]] incoloro.<ref name="multiple">Boron W, Boulpaep E. Medical Physiology: a cellular and molecular approach, 2005. 984-986. Elsevier Saunders, United States. ISBN 1-4160-2328-3</ref> Todo Anyo urobilinogenurobilinóxeno thatque remainspermanece in theno colon isconvértese converted toen [[stercobilinogenestercobilinóxeno]] ande finallyfinalmente oxidizedé tooxidado a stercobilinestercobilina, whicha iscal responsibleé forresponsable theda browncor color ofcastaña humandas feces.<ref name="multiple">Boron W, Boulpaep E. Medical Physiology: a cellular and molecular approach, 2005. 984-986. Elsevier Saunders, United States. ISBN 1-4160-2328-3</ref> Stercobilin is then excreted in the feces.<ref name="multiple 2">Seyfried H, Klicpera M, Leithner C, Penner E (1976). “Bilirubin metabolism”. Wien Klin Wochenschr. 88:477-82. PMID 793184</ref>
 
== Papel en enfermidades ==