Diferenzas entre revisións de «Citocromo c»

== Localización extramitocondrial ==
 
CytochromeEn ccondicións isfisiolóxicas widelyacéptase believedxeneralizadamente toque beo localizedcitocromo''c'' solely in the mitochondrialestá intermembranelocalizado space underno normalespazo physiologicalintermembrana conditionsmitocondrial.<ref name="pmid9242927">{{cite journal | author = Neupert W | title = Protein import into mitochondria | journal = Annu. Rev. Biochem. | volume = 66 | issue = | pages = 863–917 | year = 1997 | pmid = 9242927 | doi = 10.1146/annurev.biochem.66.1.863 }}</ref> TheA releaseliberación ofdo citocromo cytochrome-c fromda mitochondriamitocondria toao the cytosol[[citosol]], whereonde itactiva activatesa thefamilia das [[caspase]]s family ofdas [[proteasesprotease]]e iscrese believedque toé beo primaryprincipal triggeractivador leadingque to thelugar onsetao ofcomezo apoptosisda apoptose.<ref name="pmid9558479">{{cite journal | author = Kroemer G, Dallaporta B, Resche-Rigon M | title = The mitochondrial death/life regulator in apoptosis and necrosis | journal = Annu. Rev. Physiol. | volume = 60 | issue = | pages = 619–42 | year = 1998 | pmid = 9558479 | doi = 10.1146/annurev.physiol.60.1.619 }}</ref> HoweverPorén, detailedestudos immunoelectronmicroscópicos microscopicinmunoelectrónicos studiesdetallados withcon ratpreparacións tissuesde sectionstecidos employingde cytochromeratas empregando [[anticorpo]]s específicos para o citocromo ''c-specific'' antibodiesproporcionaron providefortes compellingevidencias evidencede thatque cytochrome-o citocromo ''c'' underen normalcondicións cellularnormais conditionscelulares isestá alsotamén presentpresente aten extramitochondriallocalizacións locationsextramitocondriais.<ref name="Soltys_2001">{{cite journal | author = Soltys BJ, Andrews DW, Jemmerson R, Gupta RS | title = Cytochrome-C localizes in secretory granules in pancreas and anterior pituitary | journal = Cell Biol. Int. | volume = 25 | issue = 4 | pages = 331–8 | year = 2001 | pmid = 11319839 | doi = 10.1006/cbir.2000.0651 }}</ref> InNas pancreatic[[célula pancreática acinar|células cellspancreáticas andacinares]] thee da [[pituitaria anterior pituitary]], strongdetectouse andunha specificpresenza presenceforte ofe cytochrome-específica de citocromo ''c'' wasnos detected[[gránulo (bioloxía)|gránulos]] de in [[zymogencimóxeno]] granulese andnos ingránulos da [[growthhormona hormonedo crecemento]], granules respectivelyrespectivamente. InNo the[[páncreas]] pancreas,o cytochrome-citocromo ''c'' wastamén alsose found inatopou condensingen [[vacuolesvacúolo]]s andcondensados ine the acinarno [[Lumen_lume (anatomybioloxía)|lumenlume]+ dos [[acino]]s. TheA extramitochondriallocalización localizationextramitocondrial ofdo cytochromecitocromo ''c'' wasé shownespecífica, toxa beque specificdesaparece ascompletamente itdespois wasda completedadsorción abolisheddo uponanticorpo adsorptionprimario ofco thecitocromo primary''c'' antibody with the purified cytochrome cpurificado.<ref name="Soltys_2001" /> TheA presencepresenza ofde cytochrome-citocromo ''c'' outsidefóra ofda mitochondriamitocondria aten specificlocalizacións locationespecíficas underbaixo normalcondicións physiologicalfisiolóxicas conditionsnormais raisesformula importantimportantes questionscuestións concerningsobre itsa cellularsúa functionfunción andcelular e os mecanismos translocationde mechanismtranslocación.<ref name="Soltys_2001" /> BesidesAdemais cytochromede para o citocromo ''c'', extramitochondrialesta localizationlocalización hasextramitocondrial also beentamén observedse forobservou largeen numbersmoitas ofoutras otherproteínas proteinsmitocondriais includingincluíndo thoseas encodedcodificadas bypolo mitochondrialpropio DNA[[ADN mitocondrial]].<ref name="pmid18575266">{{cite journal | author = Gupta RS, Ramachandra NB, Bowes T, Singh B | title = Unusual cellular disposition of the mitochondrial molecular chaperones Hsp60, Hsp70 and Hsp10 | journal = Novartis Found. Symp. | volume = 291 | issue = | pages = 59–68; discussion 69–73, 137–40 | year = 2008 | pmid = 18575266 | doi = }}</ref><ref name="pmid16133117">{{cite journal | author = Sadacharan SK, Singh B, Bowes T, Gupta RS | title = Localization of mitochondrial DNA encoded cytochrome c oxidase subunits I and II in rat pancreatic zymogen granules and pituitary growth hormone granules | journal = Histochem. Cell Biol. | volume = 124 | issue = 5 | pages = 409–21 |date=November 2005 | pmid = 16133117 | doi = 10.1007/s00418-005-0056-2 }}</ref><ref name="Soltys_2000">{{cite journal | author = Soltys BJ, Gupta RS | title = Mitochondrial proteins at unexpected cellular locations: export of proteins from mitochondria from an evolutionary perspective | journal = Int. Rev. Cytol. | volume = 194 | issue = | pages = 133–96 | year = 2000 | pmid = 10494626 | doi = }}</ref> ThisIsto raisesabre thea possibilityposibilidade aboutde existenceque ofexistan yetmecanismos unidentifiedespecíficos specificpara mechanismsa fortranslocación proteinde translocationproteínas frommitocondriais mitochondriaaínda tonon otheridentidicados cellularque as pasan desde as mitocondrias ao citosol para ir a outros destinos destinationscelulares.<ref name="Soltys_2000" /><ref name="pmid10322429">{{cite journal | author = Soltys BJ, Gupta RS | title = Mitochondrial-matrix proteins at unexpected locations: are they exported? | journal = Trends Biochem. Sci. | volume = 24 | issue = 5 | pages = 174–7 |date=May 1999 | pmid = 10322429 | doi = }}</ref>
 
== Notas ==
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