Ligando: Diferenzas entre revisións

BivalentOs ligandsligandos consistbivalentes ofconstan twode connecteddúas moleculesmoléculas asconectadas. ligands,Utilízanse anden areinvestigación usedcientífica inpara scientificdetectar researchreceptores todímeros detecte [[GPCRinvestigar oligomer|receptoras dimers]]súas andpropiedades. toOs ligandos investigatebivalentes theirson properties.xeralmente Bivalentgrandes ligandse aretenden usuallya largenon andser tendde not‘tipo tofármaco’, be ‘drug-like’,o limitingque theirlimita applicabilitya insúa clinicalaplicabilidade settingsclínica.<ref>{{cite journal | pmid = 21520422 | doi=10.1002/cmdc.201100101 | volume=6 | issue=6 | title=Design strategies for bivalent ligands targeting GPCRs | year=2011 | month=June | journal=ChemMedChem | pages=963–74 | last1 = Shonberg | first1 = Jeremy | last2 = Scammells | first2 = Peter J. | last3 = Capuano | first3 = Ben}}</ref><ref>{{cite journal | pmid = 19075611 | volume=5 | issue=4 | title=Bivalent ligands as specific pharmacological tools for G protein-coupled receptor dimers | year=2008 | month=December | journal=Curr Drug Discov Technol | pages=312–8 | doi = 10.2174/157016308786733591 | last1 = Berque-Bestel | first1 = I | last2 = Lezoualc'h | first2 = F | last3 = Jockers | first3 = R}}</ref> See Lipinski’s [[rule of five]].