|
==Interaccións==
A PTPRC hasinteracciona been shown to [[Protein-protein interaction|interact]] withcon [[LYN]],<ref name="pmid7516335">{{cite journal | author = Brown VK, Ogle EW, Burkhardt AL, Rowley RB, Bolen JB, Justement LB | title = Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45 | journal = J. Biol. Chem. | volume = 269 | issue = 25 | pages = 17238–44 | year = 1994 | month = June | pmid = 7516335 | doi = }}</ref> [[Lck]],<ref name="pmid8473339">{{cite journal | author = Koretzky GA, Kohmetscher M, Ross S | title = CD45-associated kinase activity requires lck but not T cell receptor expression in the Jurkat T cell line | journal = J. Biol. Chem. | volume = 268 | issue = 12 | pages = 8958–64 | year = 1993 | month = April | pmid = 8473339 | doi = }}</ref><ref name="pmid8576115">{{cite journal | author = Ng DH, Watts JD, Aebersold R, Johnson P | title = Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro | journal = J. Biol. Chem. | volume = 271 | issue = 3 | pages = 1295–300 | year = 1996 | month = January | pmid = 8576115 | doi = 10.1074/jbc.271.3.1295}}</ref> [[SKAP1]]<ref name="pmid11909961">{{cite journal | author = Wu L, Fu J, Shen SH | title = SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription | journal = Mol. Cell. Biol. | volume = 22 | issue = 8 | pages = 2673–86 | year = 2002 | month = April | pmid = 11909961 | pmc = 133720 | doi = 10.1128/MCB.22.8.2673-2686.2002 }}</ref> ande [[GANAB]].<ref name="pmid9148925">{{cite journal | author = Arendt CW, Ostergaard HL | title = Identification of the CD45-associated 116-kDa and 80-kDa proteins as the alpha- and beta-subunits of alpha-glucosidase II | journal = J. Biol. Chem. | volume = 272 | issue = 20 | pages = 13117–25 | year = 1997 | month = May | pmid = 9148925 | doi = 10.1074/jbc.272.20.13117 }}</ref><ref name="pmid10921916">{{cite journal | author = Baldwin TA, Gogela-Spehar M, Ostergaard HL | title = Specific isoforms of the resident endoplasmic reticulum protein glucosidase II associate with the CD45 protein-tyrosine phosphatase via a lectin-like interaction | journal = J. Biol. Chem. | volume = 275 | issue = 41 | pages = 32071–6 | year = 2000 | month = October | pmid = 10921916 | doi = 10.1074/jbc.M003088200 }}</ref><ref name="pmid11564800">{{cite journal | author = Baldwin TA, Ostergaard HL | title = Developmentally regulated changes in glucosidase II association with, and carbohydrate content of, the protein tyrosine phosphatase CD45 | journal = J. Immunol. | volume = 167 | issue = 7 | pages = 3829–35 | year = 2001 | month = October | pmid = 11564800 | doi = }}</ref>
Viuse recentemente que o CD45 hasinteracciona beentamén recentlycoa shownproteína toUL11 interactdo withcitomegalovirus thehumano ([[HCMV]]). UL11Esta protein.interacción Thisorixina interactionunha resultsparálise infuncional functionaltemporal paralysisdas ofcélulas [[T cell]]s.<ref name="pmid22174689">{{cite journal | author = Gabaev I, Steinbrück L, Pokoyski C, Pich A, Stanton RJ, Schwinzer R, Schulz TF, Jacobs R, Messerle M, Kay-Fedorov PC | title = The human cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45, resulting in functional paralysis of T cells | journal = PLoS Pathog. | volume = 7 | issue = 12 | pages = e1002432 | year = 2011 | month = December | pmid = 22174689 | pmc = 3234252 | doi = 10.1371/journal.ppat.1002432 }}</ref>
==Importancia clínica==
|
