CD4: Diferenzas entre revisións

En [[bioloxía molecular]], o '''CD4''' ([[clúster de diferenciación]] 4) é unha [[glicoproteína]] que se encontra na superficie de células inmunes como o [[linfocito T axudante]], [[monocito]], [[macrófago]], e [[célula dendrítica]]. Descubriuse a finais da década de 1970 e orixinalmente deuselle o nome de leu-3 e T4 (debido aos [[anticorpo monoclonal|anticorpos monoclonais]] OKT4 que reaccionaban con el) antes de ser rebautizado como CD4 en 1984.<ref name="isbn0-387-12056-4">{{cite book | author = Alain Bernard | authorlink = | editor = | others = | title = Leucocyte typing: human leucocyte differentiation antigens detected by monoclonal antibodies: specification, classification, nomenclature: [report on the first international references workshop sponsored by INSERM, WHO and IUIS] | edition = | language = | publisher = Springer | location = Berlin | year = 1984 | origyear = | pages = pages 45–48 | quote = | isbn = 0-387-12056-4 | oclc = | doi = | url = | accessdate = }}</ref> Nos humanos a proteína CD4 está codificada polo [[xene]] ''CD4'' do [[cromosoma 12]].<ref name="pmid3086883">{{cite journal | author = Isobe M, Huebner K, Maddon PJ, Littman DR, Axel R, Croce CM | title = The gene encoding the T-cell surface protein T4 is located on human chromosome 12 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 83 | issue = 12 | pages = 4399–402 | year = 1986 | month = June | pmid = 3086883 | pmc = 323740 | doi = 10.1073/pnas.83.12.4399| url = http://www.pnas.org/cgi/pmidlookup?view=long&pmid=3086883 }}</ref><ref name="pmid8723724">{{cite journal | author = Ansari-Lari MA, Muzny DM, Lu J, Lu F, Lilley CE, Spanos S, Malley T, Gibbs RA | title = A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13 | journal = Genome Res. | volume = 6 | issue = 4 | pages = 314–26 | year = 1996 | month = April | pmid = 8723724 | doi = 10.1101/gr.6.4.314| url = http://www.genome.org/cgi/pmidlookup?view=long&pmid=8723724 }}</ref>

 

 

==Estrutura==