O CD4 continuescontinúa toexpresándose bena expressedmaioría in mostdos [[neoplasmneoplasma]]s derivedderivados fromde células T helper cellsaxudantes. ItÉ ispor thereforetanto possibleposible toutilizar use CD4a [[immunohistochemistryinmunohistoquímica]] ondo tissueCD4 en mostras de [[biopsybiopsia]]s samplesde totecidos identifypara mostidentificar formsa ofmaioría peripheraldas Tformas cellde [[lymphomalinfoma]]s de células T periféricas ande relatedcondicións malignantmalignas conditionsasociadas.<ref name="isbn1-84110-100-1">{{cite book | author = Kumarasen Cooper; Anthony S-Y. Leong | title = Manual of diagnostic antibodies for immunohistology | publisher = Greenwich Medical Media | location = London | year = 2003 | pages = 65 | isbn = 1-84110-100-1 }}</ref> TheEste antigenantíxeno hasfoi alsotamén beenasociado associatedcon with a number ofvarias [[autoimmunityenfermidade autoinmunitaria|autoimmuneenfermidades diseasesautoinmunitarias]] suchcomo asa [[vitiligovitilixe]] ande a [[type I diabetes mellitus de tipo I]].<ref name="pmid19843086">{{cite journal | author = Zamani M, Tabatabaiefar MA, Mosayyebi S, Mashaghi A, Mansouri P | title = Possible association of the CD4 gene polymorphism with vitiligo in an Iranian population | journal = Clin. Exp. Dermatol. | volume = 35 | issue = 5 | pages = 521–4 | year = 2010 | month = July | pmid = 19843086 | doi = 10.1111/j.1365-2230.2009.03667.x }}</ref>
