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== Función ==
O CD4 isé aun [[co-receptorcorreceptor]] thatque assistsaxuda theao [[Treceptor cellde receptorcélulas T]] (TCR) inna communicatingsúa withcomunicación ancoa [[antigen-presentingcélula cellpresentadora de antíxenos]]. UsingPor itsmedio intracelluardo domainseu dominio intraceluar, o CD4 amplifiesamplifica theo signalsinal generatedxerado by thepolo TCR byrecrutando recruiting ano [[enzymeencima]], the [[tyrosinetirosina kinasequinase]] [[lck]], whichque isé essentialesencial forna activatingactivación manyde molecularmoitos componentscompoñentes ofmoleculares theda signalingcascada cascadede ofsinalización andun activatedlinfocito T cellactivado. O CD4 alsotamén interactsinteracciona directlydirectamente withcon moléculas do [[MHC classde clase II]] moleculesna onsuperficie theda surfacecélula ofpresentadora thede antigen-presentingantíxenos cellutilizando usingo itsseu [[extracellular]]dominio domainextracelular. TheO extracellulardominio domainextracelular adoptsadopta anunha immunoglobulin-likeestrutura en [[sandwich beta-sandwich]] withde seventipo strandsinmunoglobulina incon 2sete cadeas en dúas [[folla beta|follas sheetsbeta]], informando aun [[Greek_key_motifFolla beta#Greek__motif|GreekMotivos keyestruturais topology]]comúns|motivo greca.<ref name="pmid8493535">{{cite journal | author = Brady RL, Dodson EJ, Dodson GG, Lange G, Davis SJ, Williams AF, Barclay AN | title = Crystal structure of domains 3 and 4 of rat CD4: relation to the NH2-terminal domains | journal = Science | volume = 260 | issue = 5110 | pages = 979–83 | year = 1993 | month = May | pmid = 8493535 | doi = 10.1126/science.8493535| url = }}</ref>
=== Outras interaccións ===
O CD4 hastamén also been shown to [[Protein-protein interaction|interact]]interacciona withcon [[SPG21]],<ref name=pmid11113139>{{cite journal |last=Zeitlmann |first=L |authorlink= |coauthors=Sirim P, Kremmer E, Kolanus W |year=2001|month=Mar. |title=Cloning of ACP33 as a novel intracellular ligand of CD4 |journal=J. Biol. Chem. |volume=276 |issue=12 |pages=9123–32 |publisher= |location = United States| issn = 0021-9258| pmid = 11113139 |doi = 10.1074/jbc.M009270200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Lck]]<ref name="pmid20724730">{{cite journal | author = Rudd CE, Trevillyan JM, Dasgupta JD, Wong LL, Schlossman SF | title = Pillars article: the CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes. 1988 | journal = J. Immunol. | volume = 185 | issue = 5 | pages = 2645–9 | year = 2010 | month = September | pmid = 20724730 | doi = | url = }}</ref><ref name="pmid2455897">{{cite journal | author = Rudd CE, Trevillyan JM, Dasgupta JD, Wong LL, Schlossman SF | title = The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 85 | issue = 14 | pages = 5190–4 | year = 1988 | month = July | pmid = 2455897 | pmc = 281714 | doi = 10.1073/pnas.85.14.5190| url = }}</ref><ref name="pmid2470098">{{cite journal | author = Barber EK, Dasgupta JD, Schlossman SF, Trevillyan JM, Rudd CE | title = The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 86 | issue = 9 | pages = 3277–81 | year = 1989 | month = May | pmid = 2470098 | pmc = 287114 | doi = 10.1073/pnas.86.9.3277| url = }}</ref><ref name="pmid12007789">{{cite journal | author = Hawash IY, Hu XE, Adal A, Cassady JM, Geahlen RL, Harrison ML | title = The oxygen-substituted palmitic acid analogue, 13-oxypalmitic acid, inhibits Lck localization to lipid rafts and T cell signaling | journal = Biochim. Biophys. Acta | volume = 1589 | issue = 2 | pages = 140–50 | year = 2002 | month = April | pmid = 12007789 | doi = 10.1016/S0167-4889(02)00165-9 }}</ref><ref name="pmid11854499">{{cite journal | author = Foti M, Phelouzat MA, Holm A, Rasmusson BJ, Carpentier JL | title = p56Lck anchors CD4 to distinct microdomains on microvilli | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 4 | pages = 2008–13 | year = 2002 | month = February | pmid = 11854499 | pmc = 122310 | doi = 10.1073/pnas.042689099 | url = }}</ref> ande co [[Proteinhomólogo da proteína unc-119 homolog]].<ref name="pmid14757743">{{cite journal | author = Gorska MM, Stafford SJ, Cen O, Sur S, Alam R | title = Unc119, a Novel Activator of Lck/Fyn, Is Essential for T Cell Activation | journal = J. Exp. Med. | volume = 199 | issue = 3 | pages = 369–79 | year = 2004 | month = February | pmid = 14757743 | pmc = 2211793 | doi = 10.1084/jem.20030589 }}</ref>
== Enfermidades ==
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