===Transdución de sinais===
[[Ficheiro:PIP2 cleavage to IP3 and DAG.jpg|thumb|A escisión do PIP2 a IP3 e DAG inicia a liberación de calcio e a activación da proteína quinase C.]]
In biochemical signaling, diacylglycerol functions as a [[second messenger]] [[lipid signaling|signaling lipid]], and is a product of the hydrolysis of the phospholipid [[PIP2]] (phosphatidyl inositol-bisphosphate) by the [[enzyme]] [[phospholipase]] C ([[phospholipase C|PLC]]) (a [[cell membrane|membrane]]-bound enzyme) that, through the same reaction, produces [[inositol trisphosphate]] (IP<sub>3</sub>). Although inositol trisphosphate (IP<sub>3</sub>) diffuses into the [[cytosol]], diacylglycerol (DAG) remains within the [[plasma membrane]], due to its [[hydrophobe|hydrophobic]] properties. IP<sub>3</sub> stimulates the release of calcium ions from the smooth endoplasmic reticulum, whereas DAG is a physiological activator of [[protein kinase C]] (PKC). The production of DAG in the membrane facilitates translocation of PKC from the cytosol to the [[plasma membrane]].
Diacylglycerol can be mimicked by the tumor-promoting compounds [[phorbol esters]].
In addition to activating PKC, diacylglycerol has a number of other functions in the [[cell (biology)|cell]]:
a source for [[ prostaglandin]]s
a precursor of the [[ endocannabinoid]] [[2- arachidonoylglycerol]]
an activator of a subfamily of [[TRPC]] ('''T'''ransient '''R'''eceptor '''P'''otential '''C'''anonical) cation channels, TRPC3/6/7.
== Metabolismo ==