Hidroxilo: Diferenzas entre revisións

Contido eliminado Contido engadido
Miguelferig (conversa | contribucións)
Miguelferig (conversa | contribucións)
Liña 34:
Mecanismos para eliminar os for scavenging peroxyl radicals for the protection of [[cell (biology)|cellular]] structures includes endogenous [[antioxidants]] such as [[melatonin]] and [[glutathione]], and dietary [[antioxidants]] such as [[mannitol]] and [[vitamin E]]. PMID 7776173.
 
PMID 7776173.
== Biological significance ==
 
PMID 7776173. PMID 9288572
The hydroxyl radical can damage virtually all types of macromolecules: carbohydrates, nucleic acids ([[mutation]]s), lipids ([[lipid peroxidation]]) and amino acids (e.g. conversion of [[Phe]] to m-[[Tyrosine]] and o-[[Tyrosine]]). PMID 7776173. The hydroxyl radical has a very short ''[[in vivo]]'' [[half-life]] of approximately 10<sup>−9</sup> seconds and a high reactivity.<ref>{{cite journal
| author=Sies, Helmut
| title=Strategies of antioxidant defense
| year=1993 | month=March | journal=European Journal of Biochemistry
| volume=215 | issue=2 | pages=213–219
| doi=10.1111/j.1432-1033.1993.tb18025.x
| pmid=7688300 }}</ref> This makes it a very dangerous compound to the organism. PMID 7776173. PMID 9288572
 
Unlike [[superoxide]], which can be detoxified by [[superoxide dismutase]], the hydroxyl radical cannot be eliminated by an [[enzyme|enzymatic]] reaction. Mechanisms for scavenging peroxyl radicals for the protection of [[cell (biology)|cellular]] structures includes endogenous [[antioxidants]] such as [[melatonin]] and [[glutathione]], and dietary [[antioxidants]] such as [[mannitol]] and [[vitamin E]]. PMID 7776173.
 
 
 
Hai encimas no noso corpo como a [[glicosa-6-fosfato deshidroxenase]] (G6PD) que elimina os radicais hidroxilo libres antes de que fagan dano ás células.
 
==Notas==