Diferenzas entre revisións de «Queratán sulfato»

===Corneal KSI===
TheA amountcantidade ofde KSqueratán foundsulfato inatopado thena corneacórnea isé 10 foldveces highermaior thanca itna iscartilaxe ine cartilage andde 2-4 timesa higher than4 itveces ismaior inca othernoutros tissuestecidos.<ref>{{cite journal | author = Funderburgh JL, Caterson B. and Conrad GW. | title = Distribution of proteoglycans antigenically related to corneal keratan sulfate proteoglycan | journal = J. Biol. Chem. | year=1987 | volume=262 | issue =24 | pages=11634–11640 | pmid = 2957372}}</ref> It is produced by [[corneal keratocyte]]s <!--
--><ref name="pmid12933807">{{cite journal |author=Funderburgh JL, Mann MM, Funderburgh ML |title=Keratocyte phenotype mediates proteoglycan structure: a role for fibroblasts in corneal fibrosis |journal=[[J. Biol. Chem.]] |volume=278 |issue=46 |pages=45629–37 |year=2003 |month=November |pmid=12933807 |doi=10.1074/jbc.M303292200 |url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=12933807 |pmc=2877919}}</ref> and is thought to play a role of a dynamic buffer of corneal hydration. In a rare progressive disorder called [[macular corneal dystrophy]] (MCDC), the synthesis of keratan sulfate is either absent (MCDC type I) or abnormal (MCDC type II).<!--
--><ref name="OMIM_MCDC">[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=217800 Macular dystrophy, corneal, 1] - OMIM</ref>
No queratán sulfato de tipo I non corneal, as proteínas [[osteoadherina]], [[Fibromodulina]] e [[PRELP]] dos tecidos óseo e cartilaxinoso ás que se unen as cadeas de queratán sulfato por enlace con N (''N-linked'').