Triptófano: Diferenzas entre revisións

 

===Uso como suplemento alimentario===

 

Os resultados das probas clínicas realizadas obtiveron resultados contraditorios en canto á efectividade do triptófano como sedativo, especialmente en individuos normais.<ref name="pmid6764927">{{cite journal | author = Hartmann E | title = Effects of L-tryptophan on sleepiness and on sleep | journal = Journal of psychiatric research | volume = 17 | issue = 2 | pages = 107–13 | year = 1982 | pmid = 6764927 | doi = 10.1016/0022-3956(82)90012-7 }}</ref><ref name="pmid3090582">{{cite journal | author = Schneider-Helmert D, Spinweber CL | title = Evaluation of L-tryptophan for treatment of insomnia: a review | journal = Psychopharmacology (Berl.) | volume = 89 | issue = 1 | pages = 1–7 | year = 1986 | pmid = 3090582 | doi = 10.1007/BF00175180 }}</ref><ref name="pmid4097755">{{cite journal | author = Wyatt RJ, Engelman K, Kupfer DJ, Fram DH, Sjoerdsma A, Snyder F. | title = Effects of L-tryptophan (a natural sedative) on human sleep | journal = Lancet | volume = 1970 Oct 24,2 | issue = 7678 | pages = 842–6 | year = 1970 Oct 24| pmid = 4097755 | doi = | issn = 0140-6736}}</ref> Ademais, o triptófano mostrou certa efectividade no tratamento doutras condicións tipicamente asociadas con niveis cerebrais de serotonina baixos<ref>{{cite web|title=research summary of Dr. Richard Wurtman, MIT|url=http://web.mit.edu/bcs/people/wurtman.shtml|accessdate = 2007-08-12}}</ref> como desordes premenstruais<ref name="pmid10023508">{{cite journal | author = Steinberg S, Annable L, Young SN, Liyanage N | title = A placebo-controlled clinical trial of L-tryptophan in premenstrual dysphoria | journal = Biol. Psychiatry | volume = 45 | issue = 3 | pages = 313–20 | year = 1999 | pmid = 10023508 | doi = 10.1016/S0006-3223(98)00005-5 }}</ref> e depresións estacionais.<ref name="pmid9114947">{{cite journal | author = Lam RW, Levitan RD, Tam EM, Yatham LN, Lamoureux S, Zis AP | title = L-tryptophan augmentation of light therapy in patients with seasonal affective disorder | journal = Canadian Journal of Psychiatry | volume = 42 | issue = 3 | pages = 303–6 | year = 1997 | pmid = 9114947 | doi = | issn = | url = http://ww1.cpa-apc.org:8080/Publications/Archives/CJP/1997/April/apr97_bc1.htm }}</ref><ref name="Jepson_1999">{{cite journal |author=Jepson TL, Ernst ME, Kelly MW|title=Current perspectives on the management of seasonal affective disorder|journal= J Am Pharm Assoc (Wash) |volume= 39 |issue= 6 |pages= 822–9 |year= 1999 |pmid= 10609448}}</ref> En particular, o triptófano mostrou ser moi prometedor como [[antidepresivo]] administrado só<ref name="pmid7156248">{{cite journal | author = Thomson J, Rankin H, Ashcroft GW, Yates CM, McQueen JK, Cummings SW | title = The treatment of depression in general practice: a comparison of L-tryptophan, amitriptyline, and a combination of L-tryptophan and amitriptyline with placebo | journal = Psychological medicine | volume = 12 | issue = 4 | pages = 741–51 | year = 1982 | pmid = 7156248 | doi = 10.1017/S0033291700049047| issn = }}</ref> ou xunto con fármacos antidepresivos.<ref name="pmid7156248" /><ref name="pmid11022398">{{cite journal | author = Levitan RD, Shen JH, Jindal R, Driver HS, Kennedy SH, Shapiro CM | title = Preliminary randomized double-blind [[placebo]]-controlled trial of tryptophan combined with fluoxetine to treat major depressive disorder: antidepressant and hypnotic effects | journal = Journal of psychiatry & neuroscience : JPN | volume = 25 | issue = 4 | pages = 337–46 | year = 2000 | pmid = 11022398 | doi = | issn = | url = http://www.cma.ca/index.cfm/ci_id/12652/la_id/1.htm | pmc = 1407729}}</ref> However, the reliability of these clinical trials has been questioned.<ref name="pmid10696120">{{cite journal | author = Meyers S | title = Use of neurotransmitter precursors for treatment of depression | journal = Alternative medicine review : a journal of clinical therapeutic | volume = 5 | issue = 1 | pages = 64–71 | year = 2000 | pmid = 10696120 | doi = | issn = | url = http://www.thorne.com/altmedrev/.fulltext/5/1/64.pdf }}</ref><ref name="pmid11869656">{{cite journal | author = Shaw K, Turner J, Del Mar C | editor1-last = Shaw | editor1-first = Kelly A | title = Tryptophan and 5-hydroxytryptophan for depression | journal = Cochrane database of systematic reviews (Online) | volume = | issue = 1 | pages = CD003198 | year = 2002 | pmid = 11869656 | doi = 10.1002/14651858.CD003198 }}</ref>