Proteómica: Diferenzas entre revisións

==Complexidade do problema==

 

 

In the past this was done by [[mRNA]] analysis, but this was found not to correlate with protein content.<ref>{{cite journal |author=Simon Rogers, Mark Girolami, Walter Kolch, Katrina M. Waters, Tao Liu, Brian Thrall and H. Steven Wiley |title=Investigating the correspondence between transcriptomic and proteomic expression profiles using coupled cluster models |journal=Bioinformatics |volume=24 |issue=24 |pages=2894–2900 |year=2008 |pmid=18974169 |doi=10.1093/bioinformatics/btn553|accessdate=2008-01-14}}</ref><ref>{{cite journal |author=Vikas Dhingraa, Mukta Gupta, Tracy Andacht and Zhen F. Fu |title=New frontiers in proteomics research: A perspective |journal=International Journal of Pharmaceutics |volume=299 |issue=1–2 |pages=1–18 |year=2005 |pmid=15979831 |doi=10.1016/j.ijpharm.2005.04.010|accessdate=2008-01-14}}</ref> It is now known that mRNA is not always translated into protein,<ref>{{Cite web| url = http://www.nature.com/horizon/rna/background/micrornas.html| title = The major world of microRNAs| accessdate = 2009-01-14| last = Buckingham| first = Steven| year = 2003| month= May}}</ref> and the amount of protein produced for a given amount of mRNA depends on the gene it is transcribed from and on the current physiological state of the cell. Proteomics confirms the presence of the protein and provides a direct measure of the quantity present.