CD6

CD6
Identificadores
Símbolo	CD6
Símbolos alt.	TP120
Entrez	923
HUGO	1691
OMIM	186720
RefSeq	NM_006725
UniProt	P30203
Outros datos
Locus	Cr. 11 q12

En inmunoloxía o CD6 (cluster de diferenciación 6) é un tipo de antíxeno glicoproteico situado na superficie de certas células do sistema inmunitario de mamíferos. Posúe unha masa molecular de 100-130 kDa e pola súa natureza bioquímica encádrase dentro da familia dos receptores vasoira (scavenger). A súa función na célula é unirse especificamente a CD166. Exprésase especificamente en timocitos, células T e células B en pacientes de leucemia linfática crónica. O CD6 nos humanos está codificado no xene CD6 do cromosoma 11.

Véxase tamén

Bibliografía

• Aruffo A, Melnick MB, Linsley PS, Seed B (1991). "The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins". J. Exp. Med. 174 (4): 949–52. PMC 2118957. PMID 1919444. doi:10.1084/jem.174.4.949. 
• Swack JA; Mier JW; Romain PL; et al. (1991). "Biosynthesis and post-translational modification of CD6, a T cell signal-transducing molecule". J. Biol. Chem. 266 (11): 7137–43. PMID 2016320. 
• Tsuge I; Utsumi KR; Ueda R; et al. (1985). "Assignment of gene coding human T-cell differentiation antigen, Tp120, to chromosome 11". Somat. Cell Mol. Genet. 11 (3): 217–22. PMID 3923629. doi:10.1007/BF01534678. 
• Whitney GS; Starling GC; Bowen MA; et al. (1995). "The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule binding site". J. Biol. Chem. 270 (31): 18187–90. PMID 7543097. doi:10.1074/jbc.270.31.18187. 
• Robinson WH; Neuman de Vegvar HE; Prohaska SS; et al. (1995). "Human CD6 possesses a large, alternatively spliced cytoplasmic domain". Eur. J. Immunol. 25 (10): 2765–9. PMID 7589069. doi:10.1002/eji.1830251008. 
• Wee S; Schieven GL; Kirihara JM; et al. (1993). "Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors". J. Exp. Med. 177 (1): 219–23. PMC 2190871. PMID 7678115. doi:10.1084/jem.177.1.219. 
• Bowen MA; Whitney GS; Neubauer M; et al. (1997). "Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms". J. Immunol. 158 (3): 1149–56. PMID 9013954. 
• Kobarg J; Whitney GS; Palmer D; et al. (1998). "Analysis of the tyrosine phosphorylation and calcium fluxing of human CD6 isoforms with different cytoplasmatic domains". Eur. J. Immunol. 27 (11): 2971–80. PMID 9394826. doi:10.1002/eji.1830271133. 
• Singer NG; Mitra R; Lialios F; et al. (1998). "CD6 dependent interactions of T cells and keratinocytes: functional evidence for a second CD6 ligand on gamma-interferon activated keratinocytes". Immunol. Lett. 58 (1): 9–14. PMID 9436462. doi:10.1016/S0165-2478(97)02707-7. 
• Gimferrer I; Farnós M; Calvo M; et al. (2003). "The accessory molecules CD5 and CD6 associate on the membrane of lymphoid T cells". J. Biol. Chem. 278 (10): 8564–71. PMID 12473675. doi:10.1074/jbc.M209591200. 
• Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899. 
• Shin BK; Wang H; Yim AM; et al. (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". J. Biol. Chem. 278 (9): 7607–16. PMID 12493773. doi:10.1074/jbc.M210455200. 
• Gimferrer I; Ibáñez A; Farnós M; et al. (2005). "The lymphocyte receptor CD6 interacts with syntenin-1, a scaffolding protein containing PDZ domains". J. Immunol. 175 (3): 1406–14. PMID 16034076. 
• Kato Y; Tanaka Y; Hayashi M; et al. (2006). "Involvement of CD166 in the activation of human gamma delta T cells by tumor cells sensitized with nonpeptide antigens". J. Immunol. 177 (2): 877–84. PMID 16818742. 
• Ibáñez A; Sarrias MR; Farnós M; et al. (2006). "Mitogen-activated protein kinase pathway activation by the CD6 lymphocyte surface receptor". J. Immunol. 177 (2): 1152–9. PMID 16818773. 
• Hassan NJ; Simmonds SJ; Clarkson NG; et al. (2006). "CD6 Regulates T-Cell Responses through Activation-Dependent Recruitment of the Positive Regulator SLP-76". Mol. Cell. Biol. 26 (17): 6727–38. PMC 1592849. PMID 16914752. doi:10.1128/MCB.00688-06. 
• Castro MA; Oliveira MI; Nunes RJ; et al. (2007). "Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse". J. Immunol. 178 (7): 4351–61. PMID 17371992. 
• Sarrias MR; Farnós M; Mota R; et al. (2007). "CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock". Proc. Natl. Acad. Sci. U.S.A. 104 (28): 11724–9. PMC 1913855. PMID 17601777. doi:10.1073/pnas.0702815104. 

Ligazóns externas

• MeshName - CD6+protein,+human [1]