CD11c

O CD11c (cluster de diferenciación 11c) ou cadea alfa X de integrina é unha subunidade de proteína transmembrana de tipo I que se expresa en altos niveis na maioría das células dendríticas humanas, e tamén en monocitos, macrófagos, neutrófilos, e algunhas células B que está codificada no xene ITGAX do cromosoma 16 humano. O CD11c induce a activación celular e axuda a desencadear a explosión respiratoria de neutrófilo. Exprésase en moitas tricoleucemias, leucemias non linfocíticas agudas, e algunhas leucemias linfocíticas crónicas de células B.

Proteína ITGAX ou CD11c. (baseado en PDB 1n3y).

O xene ITGAX codifica a cadea alfa X de integrina. As integrinas son proteínas integrais de membrana heterodímeras compostas por unha cadea alfa e outra beta. A cadea alfa X de integrina combínase coa cadea beta 2 (CD18 ou ITGB2) para formar unha integrina específica de leucocitos denominada CR4 ou receptor 4 do compoñente do complemento 3b inactivado (iC3b). O complexo alfa X/beta 2 parece solapar as propiedades da integrina alpha M/beta 2 na adherencia dos neutrófilos e monocitos a células endoteliais estimuladas, e na fagocitose de partículas cubertas polo complemento.

Véxase tamén

Outros artigos

• Integrina
• CD11
• CD11a
• CD11b

Bibliografía

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• Steinman RM, Pack M, Inaba K (1997). "Dendritic cells in the T-cell areas of lymphoid organs.". Immunol. Rev. 156 (1): 25–37. PMID 9176697. doi:10.1111/j.1600-065X.1997.tb00956.x. 
• Córbi AL, Lopéz-Rodríguez C (1997). "CD11c integrin gene promoter activity during myeloid differentiation.". Leuk. Lymphoma 25 (5-6): 415–25. PMID 9250811. doi:10.3109/10428199709039028. 
• Ugarova TP, Yakubenko VP (2001). "Recognition of fibrinogen by leukocyte integrins.". Ann. N. Y. Acad. Sci. 936 (1): 368–85. PMID 11460493. doi:10.1111/j.1749-6632.2001.tb03523.x. 
• Valentin A, Lundin K, Patarroyo M, Asjö B (1990). "The leukocyte adhesion glycoprotein CD18 participates in HIV-1-induced syncytia formation in monocytoid and T cells.". J. Immunol. 144 (3): 934–7. PMID 1967280. 
• Gaidano G, Bergui L, Schena M; et al. (1990). "Integrin distribution and cytoskeleton organization in normal and malignant monocytes.". Leukemia 4 (10): 682–7. PMID 1976870. 
• Corbi AL, Garcia-Aguilar J, Springer TA (1990). "Genomic structure of an integrin alpha subunit, the leukocyte p150,95 molecule.". J. Biol. Chem. 265 (5): 2782–8. PMID 2303426. 
• Corbi AL, Larson RS, Kishimoto TK; et al. (1988). "Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA-1, Mac-1 and p150,95. Identification of a gene cluster involved in cell adhesion.". J. Exp. Med. 167 (5): 1597–607. PMC 2188934. PMID 3284962. doi:10.1084/jem.167.5.1597. 
• Corbi AL, Miller LJ, O'Connor K; et al. (1988). "cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95.". EMBO J. 6 (13): 4023–8. PMC 553883. PMID 3327687. 
• Miller LJ, Wiebe M, Springer TA (1987). "Purification and alpha subunit N-terminal sequences of human Mac-1 and p150,95 leukocyte adhesion proteins.". J. Immunol. 138 (8): 2381–3. PMID 3549901. 
• Bilsland CA, Diamond MS, Springer TA (1994). "The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domain.". J. Immunol. 152 (9): 4582–9. PMID 7512600. 
• Lecoanet-Henchoz S, Gauchat JF, Aubry JP; et al. (1995). "CD23 regulates monocyte activation through a novel interaction with the adhesion molecules CD11b-CD18 and CD11c-CD18.". Immunity 3 (1): 119–25. PMID 7621072. doi:10.1016/1074-7613(95)90164-7. 
• Garcìa-Barcina M, Winnock M, Bidaurrazaga I; et al. (1994). "Detection of cell-adhesion molecules on human liver-associated lymphocytes.". Immunology 82 (1): 95–8. PMC 1414860. PMID 8045597. 
• Philippeaux MM, Vesin C, Tacchini-Cottier F, Piguet PF (1996). "Activated human platelets express beta2 integrin.". Eur. J. Haematol. 56 (3): 130–7. PMID 8598231. doi:10.1111/j.1600-0609.1996.tb01331.x. 
• de Vree WJ, Fontijne-Dorsman AN, Koster JF, Sluiter W (1996). "Photodynamic treatment of human endothelial cells promotes the adherence of neutrophils in vitro.". Br. J. Cancer 73 (11): 1335–40. PMC 2074486. PMID 8645576. doi:10.1038/bjc.1996.255. 
• Bernstein CN, Sargent M, Gallatin WM (1998). "Beta2 integrin/ICAM expression in Crohn's disease.". Clin. Immunol. Immunopathol. 86 (2): 147–60. PMID 9473377. doi:10.1006/clin.1997.4462. 
• Shelley CS, Da Silva N, Georgakis A; et al. (1998). "Mapping of the human CD11c (ITGAX) and CD11d (ITGAD) genes demonstrates that they are arranged in tandem separated by no more than 11.5 kb.". Genomics 49 (2): 334–6. PMID 9598326. doi:10.1006/geno.1998.5232. 

Ligazóns externas

• MeshName - CD11c+Antigens [1]
• Mouse CD Antigen Chart
• Human CD Antigen Chart
• ITGAX Info with links in the Cell Migration Gateway